AON (adult onset neuropathy)

Details about the disease

AON is an inherited neurological disorder characterised by a weakness in the hind limbs, eventually leading to weakness in the front limbs. Neurological signs of this condition seem to progress gradually over three to four years.

Clinical signs

Clinical signs usually begin between 7½ to 9 years of age. These signs include weakening and unsteady hind limbs and uncoordinated movement. The weakness eventually progresses to include the front limbs. When all limbs are affected, there may also be difficulty in swallowing.

How is it inherited?

The disease is described as an autosomal-recessive condition and is unique to Cocker Spaniels. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Tests that have previously been available

DNA test - AON - Find the list tested dogs

Breeding advice and what your dog's results mean

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.