DNA test - MLS (Musladin-Leuke syndrome)

Details about the disease

MLS affects the development and structure of connective tissue and can affect multiple organs and structures, including bone, heart, skin and muscle.

Clinical signs

These problems are characterised by short outer toes on the front and sometimes all four feet, high-set creased ears on a flat skull with extra cartilage in them, slant narrowed eyes and very thick, tight skin with little scruff. Such pups are small in stature with a very stiff gait but not all affected pups will show all these signs. The short toes make them walk like a ballerina on their middle toes. They have a very good gregarious temperament although many have been reported to develop seizures. Some will live a normal life span as the condition may stabilise once they reach maturity but they are smaller than normal and some die very young of problems associated with the disease.

How is it inherited?

The disease is unique to Beagles and is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

Two lists of laboratories that test for MLS can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
Laboratories Contact details

Kennel Club CombiBreed (UK)

Available as part of an all-on one health test package for the Beagle.

Read more about CombiBreed
AHT (UK) The AHT closed down on 31 July and no longer offers this test.
Web:
www.aht.org.uk
Animal DNA Diagnostics (UK) Phone: 01223 395577
Email: Animal DNA Diagnostics
Web: www.animaldnaAnimdiagnostics.co.uk
Animal Genetics (UK) Phone: 01726 247788
Email: Animal Genetics
Web: www.animalgenetics.eu
Laboklin Phone: 0161 282 3066
Email: Laboklin
Web: www.laboklin.co.uk
Pet Genetics Lab Phone: 01624 679 720
Email: Pet Genetics Lab
Web: www.petgeneticslab.co.uk  

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories Contact details
Antagene (France) Email: Antagene
Web: www.antagene.com/en
Genetic Technologies (Australia) Web: www.animalnetwork.com.au
Genomia (Czech Republic) Email: Genomia
Web: www.genomia.cz
MyDogDNA (Finland) Email: MyDogDNA
Web: www.mydogdna.com
Paw Print Genetics (USA) Email: Paw Print Genetics
Web: www.pawprintgenetics.com
University of California (USA) Web: www.vgl.ucdavis.edu
Van Haeringen (Holland) Email: Van Haeringen
Web: www.vhlgenetics.com
VetGen (USA)

Web: www.vetgen.com

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:

How to responsibly breed from your DNA-tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.