DNA test - IGS (Imerslun-Gräsbeck syndrome/Cobalamin malabsorption)

Details about the disease

This clinical condition occurs because vitamin B12 is not absorbed properly in the small intestine. Vitamin B12 is needed for normal cell growth and in conjunction with iron and folic acid; it ensures that the nervous system functions properly.

Clinical signs

First signs usually appear early in a dog’s life and include a loss of appetite and lethargy (lack of energy). Puppies with this disorder will fail to grow normally. Anaemia (reduced number of red blood cells) is also a result of this condition and this will cause affected puppies to become weak with a decreased ability to exercise.

How is it inherited?

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

Two lists of laboratories that test for IGS can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
Laboratories Contact details

Kennel Club CombiBreed (UK)

Available as part of an all-on one health test package for the:

  • Beagle
  • Border Collie

Read more about CombiBreed

Animal DNA Diagnostics (UK)

Phone: 01223 395577
Email: Animal DNA Diagnostics 

Web: www.animaldnadiagnostics.co.uk

 

AHT (UK)

For Beagles only

The AHT closed down on 31 July and no longer offers this test.
Web: www.aht.org.uk

Laboklin (UK)

Phone: 0161 282 3066
Email: Laboklin 
Web: www.laboklin.co.uk

Pet Genetics Lab

Phone: 01624 679 720
Email: Pet Genetics Lab 
Web: www.petgeneticslab.co.uk

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

 

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories  Contact details
Animal Genetics (UK) Email: Animal Genetics 
Web: www.animalgenetics.eu
Genomia (Czech Republic) Email: Genomia 
Web: www.genomia.cz
MyDogDNA (Finland) Email: MyDogDNA 
Web: www.mydogdna.com
Paw Print Genetics (USA) Email: Paw Print Genetics
Web: www.pawprintgenetics.com
University of California (USA) Web: www.vgl.ucdavis.edu

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:

How to responsibly breed from your DNA-tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.