DNA test - IGS (Imerslun-Gräsbeck syndrome/Cobalamin malabsorption)

Details about the disease

This clinical condition occurs because vitamin B12 is not absorbed properly in the small intestine. Vitamin B12 is needed for normal cell growth and in conjunction with iron and folic acid; it ensures that the nervous system functions properly.

Clinical signs

First signs usually appear early in a dog’s life and include a loss of appetite and lethargy (lack of energy). Puppies with this disorder will fail to grow normally. Anaemia (reduced number of red blood cells) is also a result of this condition and this will cause affected puppies to become weak with a decreased ability to exercise.

How is it inherited?

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories we record and publish the results from?

To find out which laboratories The Kennel Club is able to record results from, and which laboratories will send results directly to The Kennel Club, please refer to our website.

Please be aware, The Kennel Club has a set of criteria that we request DNA testing laboratories to meet to enable us to record their results, helping to maintain and protect the integrity of results that appear on a dog’s record. We strongly advise that customers ensure their chosen laboratory is included on our list if they wish The Kennel Club to record and publish the results. Results from laboratories not included on this list will not be recorded.

Breeding advice and what your dog's results mean

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.