DNA test - Fuco. (Fucosidosis)

Details about the disease

Fuco is characterised by deteriorating signs of the nervous system that progress over a period of several months, sometimes from an early age. The enzyme alpha-L-fucosidase is one of many required to break down complex compounds into simple molecules that the body can use. In affected dogs, those carrying two copies of the mutant gene, this enzyme is absent, the pathway is blocked and toxic compounds build up in the cells of the affected animal. The cells of the nervous system are particularly sensitive to these toxic intermediates. The disease is severe, progressive and ultimately fatal. It affects young adults, usually between 18 months and 4 years of age.

Clinical signs

Signs include incoordination and ataxia (loss of control of movement), change in temperament, loss of learned behaviour, loss of balance, apparent deafness, visual impairment and varying degrees of depression.

How is it inherited?

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

Two lists of laboratories that test for Fucosidosis can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
Laboratories Contact details

Kennel Club CombiBreed (UK)

Available as part of an all-on one health test package for English Springer Spaniels.

Read more about CombiBreed
AHT (UK)

 

The AHT closed down on 31 July and no longer offers this test.
Web: www.aht.org.uk

Animal Genetics (UK)

Phone: 01726 247788
Email: Animal Genetics
Web: www.animalgenetics.eu
Laboklin (UK) Phone: 0161 282 3066
Email: Laboklin
Web: www.laboklin.co.uk
Pet Genetics Lab (UK) Phone: 01624 679 720
Email: Pet Genetics Lab
Web: www.petgeneticslab.co.uk  

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories Contact details
Genindexe (France) Email Genindexe
Web: www.genindexe.com
Genomia (Czech Republic) Email Genomia
Web: www.genomia.cz
PennGen (USA) Email PennGen
Web: http://research.vet.upenn.edu/Default.aspx?alias=research.vet.upenn.edu/penngen
Pinmoore Animal Lab Services (UK) Phone: 01829 781855
Email Pinmoore Animal Lab Services
Web: www.palsvetlab.co.uk
Van Haeringen (Holland) Email Van Haeringen
Web: www.vhlgenetics.com

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:

How to responsibly breed from your DNA-tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.