Details about the disease
Fuco is characterised by deteriorating signs of the nervous system that progress over a period of several months, sometimes from an early age. The enzyme alpha-L-fucosidase is one of many required to break down complex compounds into simple molecules that the body can use. In affected dogs, those carrying two copies of the mutant gene, this enzyme is absent, the pathway is blocked and toxic compounds build up in the cells of the affected animal. The cells of the nervous system are particularly sensitive to these toxic intermediates. The disease is severe, progressive and ultimately fatal. It affects young adults, usually between 18 months and 4 years of age.
Clinical signs
Signs include incoordination and ataxia (loss of control of movement), change in temperament, loss of learned behaviour, loss of balance, apparent deafness, visual impairment and varying degrees of depression.
How is it inherited?
The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.
Which laboratories we record and publish the results from?
To find out which laboratories The Kennel Club is able to record results from, and which laboratories will send results directly to The Kennel Club, please refer to our website.
Please be aware, The Kennel Club has a set of criteria that we request DNA testing laboratories to meet to enable us to record their results, helping to maintain and protect the integrity of results that appear on a dog’s record. We strongly advise that customers ensure their chosen laboratory is included on our list if they wish The Kennel Club to record and publish the results. Results from laboratories not included on this list will not be recorded.
Breeding advice and what your dog's results mean
If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.
How to find out if a potential mate has been DNA tested
The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.