DNA test - SLEM (Spongiform leuco-encephalo-myelopathy)

Details about the disease

SLEM (Spongiform leuco-encephalo-myelopathy) or shaking puppy syndrome (SPS) is a relatively new condition associated with the central nervous system which usually affects puppies at around 2 weeks old, when they begin to make attempts to walk. Occasionally some puppies have started to shake at a later age of about 10 weeks old.

Clinical signs

Clinical signs include severe tremors, mainly in the hindquarters, which are seen as an uncoordinated side-to-side movement of the rear end, appearing as an excessive, uncoordinated wagging of the tail and body. These tremors cease when the puppy sleeps. Affected pups have difficulty feeding and often grow slowly. In many cases they are put to sleep because of welfare concerns but a few have recovered with careful nursing and appear to be relatively normal as adults.

How is it inherited?

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories that test for SLEM can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
Laboratories Contact details
Canine Genetic Testing (University of Cambridge UK) Email: Canine Genetic Testing
Telephone: 01223 765 860
Website www.cagt.co.uk

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories Contact details
OFA (USA) Email: Orthopedic Foundation for Animals
Web: www.ofa.org

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to

Health (The Kennel Club)

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are added to the dog's record in the registration database, and are published:

Breeding advice and what your dog's results mean

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.