DNA test - PRA (rcd4) (Progressive retinal atrophy)

Details about the disease

PRA-rcd4 (progressive retinal atrophy rod-cone degeneration 4) is a late-onset PRA mutation that causes bilateral degeneration of the retina which causes progressive vision loss, and eventually blindness. The average age of diagnosis for dogs with this form of PRA is 10 years, though there is considerable variation within breeds.

Clinical signs

The form rcd4 is characterised by puppies being born with perfect vision then developing night blindness in the first instance, before their sight begins to degenerate further later in life.

How is it inherited?

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

Two lists of laboratories that test for PRA (rcd4) can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
Laboratories Contact details

Kennel Club CombiBreed (UK)

Available as part of an all-on one health test package for:

  • Irish Setter
  • Standard Poodle
  • Tibetan Terrier
Read more about CombiBreed
Animal Genetics (UK) Phone: 01726 247788
Email: Animal Genetics
Web: www.animalgenetics.eu
Laboklin (UK) Phone: 0161 282 3066
Email: Laboklin
Web: www.laboklin.co.uk

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories Contact details
Antagene (France) Email: Antagene
Web: www.antagene.com/en
Genomia (Czech Republic) Email: Genomia
Web: www.genomia.cz
OFFA (USA) Email: OFFA
Web: www.ofa.org
Van Haeringen (Holland) Email: Van Haeringen
Web: www.vhlgenetics.com
VetGen (USA)

Web: www.vetgen.com

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:

How to responsibly breed from your DNA-tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.