Details about the disease
MDR1 is an inherited condition that makes affected dogs particularly sensitive to drugs like ivermectin (anti-parasitic) and loperamide (opioid to treat diarrhoea). In normal dogs the blood/brain barrier protects the brain cells from various drugs and toxins. P-glycoprotein is a protein which physically pumps drugs and toxins from the cerebrospinal fluid (serum-like fluid that circulates through the brain ventricles and spinal cord cavity) back into the blood circulation. The MDR-1 mutation results in an inactive P-glycoprotein which means that drugs and toxins can accumulate in the cerebrospinal fluid and begin to inhibit brain activity.
Clinical signs
The result is that exposure of affected dogs to such drugs may be an illness requiring an extended hospital stay - or even death.
How is it inherited?
The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.
Which laboratories test for this condition?
Two lists of laboratories that test for MDR1 can be found below.
Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
| Laboratories | Contact details |
|---|---|
|
Kennel Club CombiBreed (UK) Available as part of an all-in-one health test package for the:
|
Read more about CombiBreed |
| AHT (UK) | The AHT closed down on 31 July and no longer offers this test. Web: www.aht.org.uk |
| Animal DNA Diagnostics (UK) | Phone: 01223 395577 Email: Animal DNA Diagnostics Web: www.animaldnadiagnostics.co.uk |
| Animal Genetics | Phone: 01726 247788 Email: Animal Genetics Web: www.animalgAnimal Geneenetics.eu |
| Laboklin | Phone: 0161 282 3066 Email: Laboklin Veterinary Diagnostic Laboratory Web: www.laboklin.co.uk |
| Pet Genetics Lab | Phone: 01624 679 720 Email: Pet Genetics Lab Web: www.petgeneticslab.co.uk |
Where will your dog's results be published?
DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:
- in the next available Breed Records Supplement
- on our Health Test Results Finder
Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
| Laboratories | Contact details |
|---|---|
| Antagene (France) | Email:
Anta gene
Web: www.antagene.com/en |
| DDC Veterinary (USA) | Email:
Vet DNA Center
Web: www.vetdnacenter.com |
| Genetic Technologies (Australia) | Web: www.animalnetwork.com.au |
| Genindexe (France) | Email:
Genin dexe
Web: www.genindexe.com |
| Genomia (Czech Republic) | Email:
Genomia Genetic Laboratory
Web: www.genomia.cz |
| MyDogDNA (Finland) | Email:
My Dog DNA
Web: www.mydogdna.com |
| HealthGene (Canada) Only for the following breeds:
|
Email:
Health Gene
Web: www.healthgene.com |
| Paw Print Genetics (USA) | Email:
Paw Print Genetics
Web: www.pawprintgenetics.com |
| Pinmoore Animal Laboratory Services (UK) Only for the following breeds:
|
Email:
Pinmoore Animal Lab Services
Web: www.palsvetlab.co.uk |
| Van Haeringen (Holland) For Shetland Sheepdogs only. |
Email:
Van Haeringen Genetics
Web: www.vhlgenetics.com |
How to submit DNA test results to The Kennel Club
The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.
What we require on the results certificate
Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.
Where will your dog's results be published once you have submitted them?
DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:
- in the next available Breed Records Supplement
- on our Health Test Results Finder
Breeding advice and what your dog's results mean
If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.
How to find out if a potential mate has been DNA tested
The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.