DNA test - MDR1 (Multiple drug sensitivity)

Details about the disease

MDR1 is an inherited condition that makes affected dogs particularly sensitive to drugs like ivermectin (anti-parasitic) and loperamide (opioid to treat diarrhoea). In normal dogs the blood/brain barrier protects the brain cells from various drugs and toxins. P-glycoprotein is a protein which physically pumps drugs and toxins from the cerebrospinal fluid (serum-like fluid that circulates through the brain ventricles and spinal cord cavity) back into the blood circulation. The MDR-1 mutation results in an inactive P-glycoprotein which means that drugs and toxins can accumulate in the cerebrospinal fluid and begin to inhibit brain activity.

Clinical signs

The result is that exposure of affected dogs to such drugs may be an illness requiring an extended hospital stay - or even death.

How is it inherited?

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

Two lists of laboratories that test for MDR1 can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
Laboratories Contact details

Kennel Club CombiBreed (UK)

Available as part of an all-on one health test package for the:

  • Australian Shepherd,
  • Border Collie
  • German Shepherd Dog
  • Shetland sheepdog
Read more about CombiBreed
AHT (UK) The AHT closed down on 31 July and no longer offers this test.
Web:
www.aht.org.uk
Animal DNA Diagnostics (UK) Phone: 01223 395577
Email: Animal DNA Diagnostics
Web: www.animaldnadiagnostics.co.uk
Animal Genetics Phone: 01726 247788
Email: Animal Genetics
Web: www.animalgAnimal Geneenetics.eu
Laboklin Phone: 0161 282 3066
Email: Laboklin
Web: www.laboklin.co.uk
Pet Genetics Lab Phone: 01624 679 720
Email: Pet Genetics Lab
Web: www.petgeneticslab.co.uk  

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories Contact details
Antagene (France) Email: Antagene
Web: www.antagene.com/en
DDC Veterinary (USA) Email: DDC Veterinary
Web: www.vetdnacenter.com
Genetic Technologies (Australia) Web: www.animalnetwork.com.au
Genindexe (France) Email: Genindexe
Web: www.genindexe.com
Genomia (Czech Republic) Email: Genomia
Web: www.genomia.cz
MyDogDNA (Finland) Email: MyDogDNA
Web: www.mydogdna.com
HealthGene (Canada) 
Only for the following breeds:
  • Australian Shepherd
  • Rough Collie
  • Smooth Collie
  • Shetland Sheepdog
Email: HealthGene
Web: www.healthgene.com
Paw Print Genetics (USA) Email: Paw Print Genetics
Web: www.pawprintgenetics.com
Pinmoore Animal Laboratory Services (UK)
Only for the following breeds:
  • Shetland sheepdog
  • Collie (Rough)
  • Collie (Smooth)
Email: Pinmoore Animal Laboratory Services 
Web: www.palsvetlab.co.uk
Van Haeringen (Holland)
For Shetland Sheepdogs only.
Email: Van Haeringen
Web: www.vhlgenetics.com

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:

How to responsibly breed from your DNA-tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.