DNA test - LPN2 (Leonberger polyneuropathy)

Details about the disease

LPN2 is a neuromuscular disease that causes nerve loss. The condition progresses severely to the extent where the dog is unable to support its own weight.

Clinical signs

Onset of clinical signs of type 2 neuropathy are variable, ranging from less than 1 year of age to 11 years of age, and include slowly worsening exercise intolerance, gait abnormalities, degeneration of hind leg muscles. Noisy breathing, difficulties swallowing and a change in their bark may also occur.

How is it inherited?

This disease is unique to Leonbergers and is described as an autosomal-dominant condition. This means that a dog must inherit only one copy of an abnormal gene (from either its mother or its father) before its health is affected. 

Which laboratories we record and publish the results from?

To find out which laboratories The Kennel Club is able to record results from, and which laboratories will send results directly to The Kennel Club, please refer to our website.

Please be aware, The Kennel Club has a set of criteria that we request DNA testing laboratories to meet to enable us to record their results, helping to maintain and protect the integrity of results that appear on a dog’s record. We strongly advise that customers ensure their chosen laboratory is included on our list if they wish The Kennel Club to record and publish the results. Results from laboratories not included on this list will not be recorded.

Breeding advice and what your dog's results mean

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.