DNA test - FN (Familial nephropathy)

Details about the disease

Persistent high levels of protein in the urine of a young dog most often proves to be due to FN. Dogs affected with FN have a genetic defect within the glomerulus, a structure that filters blood flowing through the kidney. This defective glomerulus lacks a certain type of collagen (main protein in connective tissue) that helps to hold the filter structure together. Once the glomerulus begins to lose its ability to work properly, blood proteins leak through into the urine.

The glomerular abnormality also leads to further kidney damage, which eventually destroys the entire nephron (tiny structures that make up the kidney and cannot be replaced once damaged or destroyed). The renal disease caused by FN invariably is progressive and ultimately fatal; however, the rate of disease progression observed in affected dogs is more rapid in some individuals than in others.

Clinical signs

Dogs with FN typically develop chronic renal failure between 6 months and 2 years of age, with eventual and sometimes rapid destruction of both kidneys. The early clinical signs are the same as those associated with chronic renal failure due to any other cause. These include excessive water consumption, excessive urine volume, reduced growth rate or weight loss, poor quality hair coat, reduced appetite and vomiting.

How is it inherited?

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

Two lists of laboratories that test for FN can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
Laboratories Contact details

Kennel Club CombiBreed (UK)

Available as part of an all-on one health test package for Cocker Spaniels.

Read more about CombiBreed
Laboklin (UK) Phone: 0161 282 3066
Email: Laboklin
Web: www.laboklin.co.uk
Genetic Technologies (Australia) Web: www.animalnetwork.com.au
Pet Genetics Lab (UK) Phone: 01624 679 720
Email: Pet Genetics Lab
Web: www.petgeneticslab.co.uk  

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories Contact details
Antagene (France) Email: Antagene
Web: www.antagene.com/en
Paw Print Genetics (USA) Email: Paw Print Genetics
Web: www.pawprintgenetics.com
Van Haeringen (Holland) Email: Van Haeringen
Web: www.vhlgenetics.com
Genindexe (France) Email: Genindexe
Web: www.genindexe.com
Genomia (Czech Republic) Email: Genomia
Web: www.genomia.cz

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:

How to responsibly breed from your DNA-tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.