DNA test - COMMD1 (Copper toxicosis)

Details about the disease

CT is a hereditary disease that leads to the build-up of dietary copper in the liver, causing illness and death.

Clinical signs

This disease does not typically show any signs in the earlier stages. Clinical effects of this disorder are commonly related to any effects associated with the liver such as: weight loss, anorexia, depression, vomiting, weakness, lethargy (lack of energy) and dehydration.

As this disease progresses, the dog may encounter problems such as ecchymotic hemorrhages (bruising), and may cause melena (blood in the stool).

Without treatment, affected dogs develop liver disease and die, usually between 3 to 7 years of age.

How is it inherited?

CT is caused by the deletion in the gene COMMD1. While the test for this mutation is definitive, it is possible that there are other genetic causes of CT not yet identified.

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

Two lists of laboratories that test for COMMD1 can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to
Laboratories Contact details
AHT (UK) The AHT closed down on 31 July and no longer offers this test.
Web:
www.aht.org.uk
Animal DNA Diagnostics (UK) Phone: 01223 395577
Email: Animal DNA Diagnostics
Web: www.animaldnadiagnostics.co.uk
Laboklin (UK) Phone: 0161 282 3066
Email: Laboklin
Web: www.laboklin.co.uk
Pet Genetics Lab (UK) Phone: 01624 679 720
Email: Pet Genetics Lab
Web: www.petgeneticslab.co.uk  

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories Contact details
Genindexe (France) Email: Genindexe
Web: www.genindexe.com
Genomia (Czech Republic) Email: Genomia
Web: www.genomia.cz
Paw Print Genetics (USA) Email: Paw Print Genetics
Web: www.pawprintgenetics.com
Pinmoore Animal Services Ltd (UK) Phone: 01829 781855
Email: Pinmoore Animal Services Ltd
Web: www.palsvetlab.co.uk
Van Haeringen (Holland) Email: Van Haeringen 
Web: www.vhlgenetics.com
VetGen (USA)

Web: www.vetgen.com

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:

How to responsibly breed from your DNA-tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on The Kennel Club’s Breed Register.