DNA test - CLAD (Canine leucocyte adhesion deficiency)

Details about the disease

This disorder affects the white blood cells ability to fight infection and is caused by misshapen proteins being formed on the surface of white blood cells. These proteins usually help the white blood cells to stick to each other and other cells in order to initiate an immune response to fight infections. Affected puppies' white blood cells will not be as sticky and will not be able to fight infections as effectively. Puppies that inherit this disease usually die early in life from multiple severe infections, even when treated with massive doses of antibiotics.

Clinical signs

CLAD is characterised by recurrent, severe bacterial infections; impaired pus formation; and delayed wound healing. Infected animals usually have severe pyrexia (fever), loss of appetite and weight loss; response to antibiotic therapy is usually poor.

How is it inherited?

The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

Two lists of laboratories that test for CLAD can be found below.

Laboratories that send a copy of your dog's results straight to The Kennel Club, so you don't have to.
Laboratories  Contact details

Kennel Club CombiBreed (UK)

Available as part of an all-on one health test package for Irish Setters.

Read more about CombiBreed
AHT (UK) The AHT closed down on 31 July and no longer offers this test
Web: www.aht.org.uk

Animal Genetics (UK)

(Irish Setters only)

Phone: 01726 247788
Email: Animal Genetics
Web: www.animalgenetics.eu
Laboklin (UK) Phone: 0161 282 3066
Email: Laboklin
Web: www.laboklin.co.uk
Pet Genetics Lab (UK) Phone: 01624 679 720
Email: Pet Genetics Lab
Web: www.petgeneticslab.co.uk  

Where will your dog's results be published?

DNA test results from these laboratories are sent directly to The Kennel Club and are recorded on to the dog's record in the registration database, and are published:

Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
Laboratories Contact details

Antagene (France)

(Irish Setters only)

Email: Antagene
Web: www.antagene.com/en
Genindexe (France) Email: Genindexe
Web: www.genindexe.com
Genomia (Czech Republic) Email: Genomia
Web: www.genomia.cz

HealthGene (Canada)

(Irish Setters only)

Email: HealthGene
Web: www.healthgene.com
Paw Print Genetics (USA) Email: Paw Print Genetics 
Web: www.pawprintgenetics.com

Pinmoore Animal Lab Services (UK)

(Irish Setters only)

Phone: 01829 781855
Email: Pinmoore Animal Lab Services 
Web: www.palsvetlab.co.uk

Van Haeringen (Holland)

(Irish Setters only)

Email: Van Haeringen  
Web: www.vhlgenetics.com

How to submit DNA test results to The Kennel Club

The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.

What we require on the results certificate

Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.

Where will your dog's results be published once you have submitted them?

DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:

How to responsibly breed from your DNA-tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.

How to find out if a potential mate has been DNA tested

The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.