Screening Scheme Description

DNA test - HUU

Details about the disease

In affected dogs, uric acid does not dissolve easily in urine and accumulates. The excessive amount of uric acid forms crystals which lead to urinary calculi (stones), which may require surgery.

Clinical signs

The changes in the urine are generally present from birth. However it usually takes some time for crystals to form and combine into stones that cause problems, most often between 3 and 6 years of age. The signs you will see in your dog depend on where in the urinary tract the stones end up. They collect most commonly in the bladder, in which case you may see blood in the urine, difficulty and pain in urinating, and small frequent amounts of urine.

Urinary tract obstruction is a serious condition that occurs when a stone completely blocks the urethra and blocks the outflow of urine (more common in male dogs that have a smaller urethra). Signs include straining to urinate, vomiting and loss of appetite, weakness and lethargy (lack of energy), due to toxins building up in the body.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link


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