Screening Scheme Description

DNA test - PHPT
Primary HyperParathyroidism


Details about the disease

This condition leads to increased activity of the parathyroid glands (small glands in the neck), a gland which is important in the regulation of calcium and phosphorus in the body. The excess of parathyroid hormone causes problems in the bones and kidneys. PHPT is thought to be the second most common cause of pathologic hypercalcemia (high levels of calcium in the blood) in dogs.

Clinical signs

In the early phases of this disease, the affected dogs tend to be relatively free of clinical effects except for increased drinking and urination. This condition affects middle aged to older dogs with a mean age of approximately 10.5 years. The gradual onset of clinical effects includes weakness, lethargy (lack of energy), shaking and sometimes weight loss. Many have concurrent calcium containing urolithiasis (bladder or kidney stones). As the hypercalcemia (high levels of calcium in the blood) becomes more profound, organ damage occurs, including possible damage to bones as well as severe kidney damage.

How it is inherited

The disease is described as an autosomal dominant condition. This means that a dog must inherit only one copy of an abnormal gene (one from its mother or one from its father) before its health is affected.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link


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