Screening Scheme Description

DNA test - CLAD
Canine leucocyte adhesion deficiency

Irish Red & White Setter

Details about the disease

This disorder affects the white blood cells ability to fight infection and is caused by misshapen proteins being formed on the surface of white blood cells. These proteins usually help the white blood cells to stick to each other and other cells in order to initiate an immune response to fight infections. Affected puppies white blood cells will not be as sticky and will not be able to fight infections as effectively. Puppies that inherit this disease usually die early in life from multiple severe infections, even when treated with massive doses of antibiotics.

Clinical signs

CLAD is characterized by recurrent, severe bacterial infections; impaired pus formation; and delayed wound healing. Infected animals usually have severe pyrexia (fever), loss of appetite and weight loss; response to antibiotic therapy is usually poor.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link


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