Irish Setter DNA screening

Distinguishing between clear, carrier and affected dogs

Clear dogs have no copies of the mutant gene responsible for the condition and will neither develop the condition nor pass the gene on to their offspring.

Carrier dogs have one copy of the normal gene and one copy of the mutant gene; they will not develop the condition, but will pass a mutant gene on to approximately half of their offspring.

Affected dogs have two copies of the mutant gene that causes the condition and will develop the disease.

Canine Leucocyte Adhesion Deficiency (CLAD)

Important information about the DNA Test Control Scheme - CLAD

As of 1st July 2005 the Kennel Club will only register Irish Setters that are proven clear of the CLAD mutation, either by direct DNA testing or by virtue of having parents that are proven to be clear of the CLAD mutation (i.e. hereditarily clear).

As of 1st January 2008 the Kennel Club will cease to routinely accept any new registrations for Irish Setter progeny produced from a CLAD carrier parent mated to a clear parent (either DNA tested clear or hereditarily clear).  Breeders wishing to register progeny from a carrier after this date will need to apply for permission prior to the proposed mating, and applications will be dealt with on a case-by-case basis, involving input from the breed clubs.

If such permission is given and a carrier is mated to a DNA-tested clear, or hereditarily clear, dog, all progeny must be DNA tested and registered with the KC as either CLAD clear or carrier.

The Kennel Club will place Kennel Club endorsements on the carrier progeny such that if they are bred from, without the necessary approval sought beforehand, their progeny will not be able to be registered with the Kennel Club.



Progressive Retinal Atrophy (PRA - rcd 1)

Important information

With effect from 1st January 2010, the Kennel Club will only register Irish Setters that are proven to be clear of PRA-rcd1 (Progressive Retinal Atrophy) or hereditarily clear of PRA  e.g. both parents are clear.


Progressive Retinal Atrophy (GPRA rcd-4)




Related Topics

Dna Screening Schemes DNA Screening
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