Details about the disease
This condition leads to increased activity of the parathyroid glands (small glands in the neck), a gland which is important in the regulation of calcium and phosphorus in the body. The excess of parathyroid hormone causes problems in the bones and kidneys. PHPT is thought to be the second most common cause of pathologic hypercalcemia (high levels of calcium in the blood) in dogs.
In the early phases of this disease, the affected dogs tend to be relatively free of clinical effects except for increased drinking and urination. This condition affects middle aged to older dogs with a mean age of approximately 10½ years. The gradual onset of clinical effects includes weakness, lethargy (lack of energy), shaking and sometimes weight loss. Many have concurrent calcium containing urolithiasis (bladder or kidney stones). As the hypercalcemia (high levels of calcium in the blood) becomes more profound, organ damage occurs, including possible damage to bones as well as severe kidney damage.
How is it inherited?
The disease is described as an autosomal dominant condition. This means that a dog must inherit only one copy of an abnormal gene (one from its mother or one from its father) before its health is affected.
Which laboratories test for this condition?
A list of laboratories that test for PHPT can be found below.
Laboratories that do not send a copy of your dog's results to The Kennel Club. You'll need to do this yourself.
|Cornell University (USA)||Email:
How to submit DNA test results to The Kennel Club
The laboratories listed above do not send your dog's DNA test results to The Kennel Club. To have these results placed on your dog's record please submit them yourself by scanning and emailing them to our health results team.
What we require on the results certificate
Please note that we require at least two forms of identification on the result certificate. These must include the dog's microchip or tattoo number along with either the dog's registered name or registered number. Results without these details cannot be accepted by us.
Where will your dog's results be published once you have submitted them?
DNA test results received by The Kennel Club are recorded on to the dog's record in the registration database, and are published:
- in the next available Breed Records Supplement
- on our Health Test Results Finder
Breeding advice and what your dog's results mean
If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and DNA testing information.
How to find out if a potential mate has been DNA tested
The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.