Glossary

Screening Scheme Description

DNA test - PRA (rcd4)
Progressive Retinal Atrophy

Details about the disease

PRA-rcd4 (Progressive Retinal Atrophy rod-cone degeneration 4) is a late-onset PRA mutation that causes bilateral degeneration of the retina which causes progressive vision loss, and eventually blindness. The average age of diagnosis for dogs with this form of PRA is 10 years, though there is considerable variation within breeds.

Clinical signs

The form rcd4 is characterised by puppies being born with perfect vision then developing night blindness in the first instance, before their sight begins to degenerate further later in life.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

For advice on breeding your dog for health, why not visit our information guide

www.thekennelclub.org.uk/media/451962/breeding_health.pdf

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link http://www.thekennelclub.org.uk/health/for-breeders/dna-testing-simple-inherited-disorders/worldwide-dna-tests/

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link http://bit.ly/2oSbtnn.

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link http://bit.ly/1jyCFnc.

 

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