Glossary

Screening Scheme Description

DNA test - PRA (rcd1)
Progressive retinal atrophy - rcd1

Details about the disease

Generalised progressive retinal atrophy (gPRA) is a disease of the retina. This tissue, located inside the back of the eye, contains specialised cells called photoreceptors that absorb the light focused on them by the eye’s lens, and converts this light into electrical nerve signals which are then interpreted by the brain as vision. These photoreceptors are divided into two groups; the cones which aid bright light and colour vision, and the rods which facilitate low light or night vision.

Clinical signs

Affected pups begin showing signs of night-blindness by 6 weeks of age, and by 1-2 years of age most affected dogs are completely blind.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link http://www.thekennelclub.org.uk/health/for-breeders/dna-testing-simple-inherited-disorders/worldwide-dna-tests/

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link http://bit.ly/2oSbtnn.

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link http://bit.ly/1jyCFnc.

 

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