Screening Scheme Description

Mucopolysaccharidosis Type IIIB

Details about the disease

MPS IIIB interferes with the body’s ability to break down large sugar molecules, the accumulation of which can lead to disruption of cell function. The particular accumulation in this condition mostly affects the brains function.

Clinical signs

The clinical signs appear between 2-4 years of age and are associated with the cerebellum, a part of the brain which plays an important role in balance and smooth, coordinated movement. Effects include tremor, difficulty in balancing, walking, and negotiating obstacles such as stairs. The disease is progressive.

How it is inherited

The disease is described as a recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link


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