Glossary

Screening Scheme Description

DNA test - MAC
Mycobacterium Avium Complex

Details about the disease

MAC is a defective condition of the immune system which leads to an overwhelming systemic infection in affected dogs and is considered a serious and lethal disease. It is a zoonotic disease which means it can be transmitted from animals to humans and vice versa.

Clinical signs

Clinical signs lethargy, lack of appetite, weight loss, weakness, diarrhoea, conjunctivitis and nasal discharge. The disease eventually affects lymph nodes, the spleen and liver.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

For advice on breeding for health, why not visit our information guide www.thekennelclub.org.uk/media/451962/breeding_health.pdf

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link http://www.thekennelclub.org.uk/health/for-breeders/dna-testing-simple-inherited-disorders/worldwide-dna-tests/

 

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