Screening Scheme Description

DNA test - LPN1
Leonberger Polyneuropathy

Details about the disease

LPN1 is a neuromuscular disease that causes nerve loss. The condition progresses severely to the extent where the dog is unable to support its own weight.

Clinical signs

Clinical signs of type 1 neuropathy usually begin at 2-4 years old, and include slowly worsening exercise intolerance, gait abnormalities, degeneration of hind leg muscles. Noisy breathing, difficulties swallowing and a change in their bark may also occur.

How it is inherited

This disease is unique to Leonbergers and is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link


Copyright © The Kennel Club Limited 2020. The unauthorised reproduction of text and images is strictly prohibited.