Screening Scheme Description

DNA test - LOA
Late Onset Ataxia

Details about the disease

Late onset ataxia is characterised by worsening incoordination and loss of balance, which can make everyday tasks and moving difficult. There is no treatment for this condition and affected dogs are often put to sleep around 2 years after onset.

Clinical signs

Affected dogs begin showing signs between 6 and 12 months of age. These signs can include changes in the way the dog walks (often weaving of the hind limbs) and some difficulty balancing.

How it is inherited

The disease is caused by a mutation in the CAPN1 gene. The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link


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