Glossary

Screening Scheme Description

DNA test - GN
Greyhound Neuropathy

Details about the disease

GN is due to mutation in the NDRG1 gene. The protein produced by this gene is found in the fluid inside cells and is involved in stress responses, hormone responses, cell growth, and cell differentiation. A mutation in this gene has a link to nerve dysfunction.

Clinical signs

Clinical effects of GN may include muscle weakness, exercise intolerance and a “bunny-hopping” gait. This neurological disease often first presents in young dogs (around three to nine months) and may rapidly progress within their first year.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link http://www.thekennelclub.org.uk/health/for-breeders/dna-testing-simple-inherited-disorders/worldwide-dna-tests/

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link http://bit.ly/2oSbtnn.

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link http://bit.ly/1jyCFnc.

 

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