Glossary

Screening Scheme Description

DNA test - Cobalamin Malabsorption

Details about the disease

This clinical condition occurs because Vitamin B12 is not absorbed properly in the small intestine. Vitamin B12 is needed for normal cell growth and in conjunction with iron and folic acid, it ensures that the nervous system functions properly.

Clinical signs

Initial signs of intestinal cobalamin malabsorption appear early in a dog’s life and include a loss of appetite and lethargy (lack of energy). Puppies with this disorder will fail to grow normally. Anaemia (reduced number of red blood cells) is also a result of this condition and this will cause affected puppies to become weak with a decreased ability to exercise

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link http://www.thekennelclub.org.uk/health/for-breeders/dna-testing-simple-inherited-disorders/worldwide-dna-tests/

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link http://bit.ly/2oSbtnn.

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link http://bit.ly/1jyCFnc.

 

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