Screening Scheme Description

DNA test - AMPN
Alaskan Malamute Polyneuropathy

Details about the disease

AMPN causes reduced stimulation of the peripheral nervous system, which is followed by nerve degeneration. This then leads to gradual muscle deterioration.

Clinical signs

Clinical signs usually occur during the first 2 years of a dog’s life and include exercise intolerance, inability to move all limbs and loss of reflexes. Dogs affected with the condition may fall down, have an abnormal gait or walk on the tops of its feet.

How it is inherited

The disease is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

For advice on breeding for health, why not visit our information guide

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link


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