Screening Scheme Description

DNA test - MLS
Musladin-Leuke Syndrome


Details about the disease

MLS affects the development and structure of connective tissue and can affect multiple organs and structures, including bone, heart, skin, and muscle.

Clinical signs

These problems are characterised by short outer toes on the front and sometimes all four feet, high set creased ears on a flat skull with extra cartilage in them, slant narrowed eyes and very thick tight skin with little scruff. Such pups are small in stature with a very stiff gait BUT not all affected pups will show all these signs. The short toes make them walk like a ballerina on their middle toes. They have a very good gregarious temperament although many have been reported to develop seizures. Some will live a normal life span as the condition may stabilise once they reach maturity but they are smaller than normal and some die very young of problems associated with the disease.

How it is inherited

The disease is unique to Beagles and is described as an autosomal recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected. A dog that inherits only one copy of the abnormal gene (from its mother or its father) will have no signs of the disease, but will be a carrier and may pass the gene on to any offspring.

Which laboratories test for this condition?

A list of laboratories and DNA tests can be found at the following link

How to responsibly breed from your DNA tested dog

If, once your dog is DNA tested, you would like to find out what their DNA test results mean, or how to select the right mate to avoid producing affected puppies, then please read our breeding advice and information on the following link

How to find out if a potential mate has been DNA tested

The Kennel Club’s “Health Test Results Finder” allows you to find the results of DNA tests carried out as part of official Kennel Club DNA testing schemes for any dog on the Kennel Club’s breed register. To access this free health tool, please follow this link


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