Important information about the DNA Test Control Scheme – CLAD

The following breeding control scheme has been agreed by representatives of the Irish Red & White Setter Breed Clubs and the Kennel Club:

• From 17th June 2003 all Irish Red & White Setters used for breeding should be either hereditarily clear of CLAD or have a CLAD DNA test before they are used for breeding.

• Identified carriers can be used for breeding, but they should only be mated to a dog that is either hereditarily clear of CLAD or one that has DNA tested clear of CLAD; carriers should not be mated to carriers.

• All of the registered offspring of a carrier mated to a clear should be clearly identified, DNA tested and registered as either tested clear or carrier.
• From 17th June 2008 the Kennel Club will refuse registration of Irish Red & White Setter puppies unless both parents have been tested clear of CLAD, or are hereditarily clear of CLAD.

• No carriers will be registered after 16th June 2008

Test Results

The test distinguishes between clear, carrier and affected dogs. Clear dogs have no copies of the mutant gene responsible for CLAD and will neither develop the condition nor pass a CLAD gene on to their offspring. Carrier dogs have one copy of the normal gene and one copy of the mutant gene; they will not develop the condition, but will pass a mutant gene on to approximately half of their offspring. Affected dogs have two copies of the mutant gene that causes CLAD and will develop the disease.

Test results from the following laboratories will automatically be sent to the Kennel Club for inclusion on its database :-

Animal Health Trust

Laboklin

Results from other laboratories may be included on the database upon owner submission and request – please email hbs@thekennelclub.org.uk for further information.

The following Irish Red & White Setters have been DNA tested for Canine Leucocyte Adhesion Deficiency (CLAD).  Tables listing Clears/Carriers (in PDF format) are available from the following links:

CLAD Irish Red & White Setters Clears

CLAD Irish Red & White Setters Carriers

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Dog Health and DNA 

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