Distinguishing between clear, carrier and affected dogs
Clear dogs have no copies of the mutant gene
responsible for the condition and will neither develop the
condition nor pass the gene on to their offspring.
Carrier dogs have one copy of the normal gene
and one copy of the mutant gene; they will not develop the
condition, but will pass a mutant gene on to approximately half of
Affected dogs have two copies of the mutant
gene that causes the condition and will develop the
Canine Leucocyte Adhesion Deficiency (CLAD)
Important information about the DNA Test Control Scheme
As of 1st July 2005 the Kennel Club will only register Irish
Setters that are proven clear of the CLAD mutation, either by
direct DNA testing or by virtue of having parents that are proven
to be clear of the CLAD mutation (i.e. hereditarily clear).
As of 1st January 2008 the Kennel Club will cease to routinely
accept any new registrations for Irish Setter progeny produced from
a CLAD carrier parent mated to a clear parent (either DNA tested
clear or hereditarily clear). Breeders wishing to register
progeny from a carrier after this date will need to apply for
permission prior to the proposed mating, and applications will be
dealt with on a case-by-case basis, involving input from the breed
If such permission is given and a carrier is mated to a DNA-tested
clear, or hereditarily clear, dog, all progeny must be DNA tested
and registered with the KC as either CLAD clear or carrier.
The Kennel Club will place Kennel Club endorsements on the carrier
progeny such that if they are bred from, without the necessary
approval sought beforehand, their progeny will not be able to be
registered with the Kennel Club.
Progressive Retinal Atrophy (PRA - rcd 1)
Progressive Retinal Atrophy (GPRA rcd-4)