Distinguishing between clear, carrier and affected dogs
Clear dogs have no copies of the mutant gene
responsible for the condition and will neither develop the
condition nor pass the gene on to their offspring.
Carrier dogs have one copy of the normal gene
and one copy of the mutant gene; they will not develop the
condition, but will pass a mutant gene on to approximately half of
Affected dogs have two copies of the mutant
gene that causes the condition and will develop the
Canine Leucocyte Adhesion Deficiency (CLAD)
The following breeding control scheme has been agreed by
representatives of the Irish Red & White Setter Breed Clubs and
the Kennel Club:
- From 17th June 2003 all Irish Red & White Setters used for
breeding should be either hereditarily clear of CLAD or have a CLAD
DNA test before they are used for breeding.
- Identified carriers can be used for breeding, but they should
only be mated to a dog that is either hereditarily clear of CLAD or
one that has DNA tested clear of CLAD; carriers should not be mated
- All of the registered offspring of a carrier mated to a clear
should be clearly identified, DNA tested and registered as either
tested clear or carrier.
- From 17th June 2008 the Kennel Club will refuse registration of
Irish Red & White Setter puppies unless both parents have been
tested clear of CLAD, or are hereditarily clear of CLAD.
- No carriers will be registered after 16th June 2008
von Willebrand's Disease (vWD)